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The inward-rectifier K + current ( I K1 ) is tightly coupled with the NKA in the polarization of the RMP ( I K1 in guinea pig myocytes following LCAC exposure at a concentration range of 1050 M ( I K1 or channel kinetics at a similar LCAC dose range ( + , Ca 2+ , and Na + currents, the suppression of I K1 was found to contribute to less to RMP depolarization than that of LCAC-mediated NKA inhibition ( Another K + -mediated electrophysiological derangement induced by LCAC application is a reduction of the APD