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In addition, ketogenic diet-induced fibroblast growth factor 21 administration significantly reduced sweet taste and alcohol preference in mice and sweet taste preference in cynomolgus monkeys, and was associated with reduced DA concentrations in the NAc (104)

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Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection ( 4.6 Overcoming challenges in translating natural compounds into clinical applications Despite promising findings, translating the therapeutic potential of natural compounds into clinical practice presents several key challenges