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If a subset of gut microbes in AD or VD (vascular dementia) is driving TMAO-associated inflammation, such inhibitors might ameliorate it [273, 274]

However, further studies are required to determine the clinical utility

Optional but recommended: baseline calcitonin and thyroid ultrasound

Ethics approval All procedures involving animals adhered strictly to the guidelines of the Institutional Animal Care and Use Committee (IACUC 2022-06-21-1, IACUC 2023-10-37-1, IACUC 2024-10-47-1, and IACUC 2025-02-77-1) of Sungkyunkwan University School of Medicine (SUSM), which is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International) and abides by the Institute of Laboratory Animal Resources (ILAR) guidelines