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Description

M.LalorS

10.1002/jor.1100140111 112 HolmS.HolmA

Arch Gen Psychiatry 64 : 11891195

Further investigation revealed hesperetin's ability to decrease expression of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL), two critical mediators of necroptosis pathways, suggesting its capacity to ameliorate DSS-induced intestinal inflammation through suppression of the RIPK3/MLKL necroptosis signaling cascade (67)