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Overall, vitamin B12 deficiency is treatable and can lead to serious neurological sequelae if left untreated, so it is important to consider vitamin B12 deficiency as a potential cause in patients with unexplained epilepsy, especially when accompanied by macrocytic anemia [85]

When rats were dosed from gestational day 7 through weaning on postnatal day 21, a statistically significant decrease in maternal femur weight of up to 14% (as compared to placebo treatment) was observed at doses equal to or greater than 138 mg/kg/day (about 34 times an oral human dose of 40 mg on a body surface area basis)

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