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When the K + concentration is high, K + diffuses into the larger extracellular space via net outwards movement guided by the astrocyte network through inwards rectifier potassium channels located in astrocyte foot processes (Kir 4.1) after causing a temporary increase in intracellular concentration (82, 83)

Weight loss is the most effective treatment for fatty liver disease, with studies showing that losing 710% of body weight can significantly reduce hepatic steatosis

The TME of NSCLC contains a large number of TAMs which influence tumor progression and patient prognosis, and specifically, M2 TAMs were shown to induce tumor aggressiveness and proliferation in NSCLC [63, 64]

Taken together, we propose that chronic GSH depletion induces redox activation of the AMPK pathway that may serve as the central link triggering mechanisms that prevent alcohol-induced liver injury (as illustrated in Fig