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For early-onset PD, the cumulative evidence is consistent with a strong heritability component (at least in white males, the only group studied to date)

Bioavailability, efficacy, safety, and regulatory status of creatine and related compounds: a critical review

Furthermore, the involvement of CHAC1 in non-malignant diseases, such as diabetes, liver injury, and respiratory disorders, adds complexity, as its therapeutic modulation could potentially worsen these conditions by disrupting GSHmetabolism and increasing oxidative stress

Calmangafodipir Targeting manganese superoxide dismutase (MnSOD) has emerged as a promising strategy to prevent OIPN symptoms [186, 187]