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d f Trypsin-like ( d ), chymotrypsin-like ( e ) and caspase-like ( f ) proteasome activity in differentiated hypoxic chondrocytes (n = 6

The pathway-associated metabolite set was used as the metabolite library, with all compounds included

Operating as a ligand for IGF1R, LR3 IGF-I binds to the alpha subunit, initiating the activation of intrinsic tyrosine kinase activity, autophosphorylating tyrosine residues in the beta subunit