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However, in a much larger randomized controlled trial of simvastatin and an antioxidant combination of 600 mg of all - rac --tocopherol (297 mg of RRR --tocopherol), 250 mg of vitamin C, and 20 mg of -carotene daily) in more than 20,000 men and women with CHD or diabetes mellitus, the antioxidant combination did not adversely affect the cardioprotective effects of simvastatin therapy over a five-year period (131)

249 In alcoholic liver disease, long-term alcohol intake increases the levels of homocysteine and SAH, decreases the SAM/SAH ratio, and directly affects cellular methylation levels

Nevertheless, the transgenic mouse model, which involves manipulating gene expression at a specific point in time and verifying the function of these genes in the context of addiction, has not been widely employed