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Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

Patients commonly see redness at the treatment site immediately following treatment which fades within 1-2 days, and are recommended to protect their treated areas from sun exposure for at least 2 weeks following treatment

The combination of methylcobalamin (mB12) with low-dose folinic acid (LDFA) and sapropterin, a synthetic form of tetrahydrobiopterin (BH4) have been studied in open-label trials while high-dose folinic acid has been studied in a double-blind placebo controlled trial