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Proteolytic stability assay To evaluate the proteolytic stability of peptides against chymotrypsin, the peptides were dissolved to 1 mg/mL and incubated with chymotrypsin (1 mg/mL) at 37C for different times (0, 1, 2, 4, 8, and 16 h)

Sodium channels, inherited epilepsy, and antiepileptic drugs

4 Hypothesis of the gut microbiota-ferroptosis axis in OA pathogenesis 4.1 Gut microbiota and abnormal iron metabolism synergistically promote joint ferroptosis 4.1.1 Gut microbiota promotes ferroptosis via hepcidin-FPN1 axis and FTN-mediated iron overload The gut microbiota modify systemic iron homeostasis through the modulating ability of microbiota to regulate the synthesis of hepatic hepcidin, an effect the subject of intense investigation