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Supplementary material The Supplementary Material for this article can be found online at: References 1 VangapanduHVHavranekOAyresMLKaipparettuBABalakrishnanKWierdaWGet al

8 , e2994 (2018)

Cocaine binds with high affinity to the norepinephrine transporter (NET) on the presynaptic nerve terminal (Kd 0.3 M), acting as a transmembrane physical plug that inhibits reuptake of norepinephrine

67,68 Accumulated toxins in the blood due to poor kidney filtration are thought to contribute to thrombosis risk by stimulating platelet (cell fragments responsible for blood clotting) and clotting factor activation