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634 AAK1 inhibitor LX-9211: Junctional protein 2-associated kinase 1 (AAK1) is widely expressed in the brain and spinal cord and is a viable target for the treatment of neuropathic pain, and BMS-986176/LX-9211 is a novel class of bis(iso)aryl ethers that are highly selective, CNS-permeable, and potent AAK1 inhibitors

In conclusion, the experimental data are well described by the model for all knock-downs, except for slight deviations for siKEAP1, where the increase in Keap1-GFP and Srxn1-GFP after DEM exposure was underestimated by the model

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