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Wolfe and Cyr, 2011) collectively referred to as amyloidosis (Metkar et al., 2024) Tau proteins representing the characteristic pathology of Alzheimers disease (Chen and Yu, 2023) are normally associated with stabilization of neuronal microtubules (Jesu et al., 2004), but give rise to fibrillar tangles along with -amyloid under a hyperphosphorylated state

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Under the same conditions, treatment with the current drug of choice, PZQ, or the clinically tested and now discontinued meclonazepam (MZM) 42 , which have different schistosomicidal mechanisms and do not inhibit TGR, resulted in no change of that ratio