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In a subsequent phase III RCT with 131 patients with PV, rilzabrutinib failed to show significant differences with regard to remission rates between the drug and placebo arm, although the proportion of participants who achieved the original primary endpoint (complete remission from week 29 to week 37 with a corticosteroid dose of up to 5 mg/day) was initially significantly higher in the rilzabrutinib group [26]

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Frontiers in Immunology 12: 756423

With ongoing innovation in CAR design, their safety, efficacy, and durability are continuously optimized across diverse disease settings