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In addition to TLR-7 agonists and TLR-7/8 agonists, M2pep-rHF-CpG nanoparticles formed by the TLR9 agonist CpG oligonucleotide (CpG ODN) are enclosed in human ferritin heavy chain (rHF) nanocage engineered by mouse M2 macrophages, these nanoparticles can be targeted to deliver to M2 TAMs and polarize M2 TAMs into M1 TAMs thereby inhibiting tumor growth (44)

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