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Glossary 4-HNE 4-hydroxynonenal ABR auditory brainstem response ALSPAC Avon Longitudinal Study of Parents and Children AUC area under the curve AUROC area under the receiver operating characteristic curve Ca 2+ calcium ion casp 3 caspase-3 casp 9 caspase-9 CDSS clinical decision support system CI confidence interval CPIC Clinical Pharmacogenetics Implementation Consortium DPOAE distortion product otoacoustic emission EAS electroacoustic stimulation ER endoplasmic reticulum GFR glomerular filtration rate GSH glutathione GSSG glutathione disulfide ICH International Council for Harmonisation IHC inner hair cell JNK c-Jun N-terminal kinase LBW low birth weight MDR-TB multidrug-resistant tuberculosis MET mechanoelectrical transduction MIPD model-informed precision dosing MLKL mixed lineage kinase domain-like protein MT-RNR1 mitochondrially encoded 12S ribosomal RNA MTO1 mitochondrial tRNA translation optimization 1 NAC N-acetylcysteine NICE National Institute for Health and Care Excellence NICU neonatal intensive care unit NOX3 NADPH oxidase 3 (NOX3)-dependent superoxide production OAE otoacoustic emissions OHC outer hair cell OR odds ratio PALOH Pharmacogenetics to Avoid Loss of Hearing PBPK physiologically based pharmacokinetic RIPK receptor-interacting protein kinase ROS reactive oxygen species RR relative risk SCC semicircular canal TDM therapeutic drug monitoring TFB1M transcription factor B1, mitochondrial TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase TRP transient receptor potential TUNEL terminal deoxynucleotidyl transferase dUTP nick end labeling VEMP vestibular evoked myogenic potential vHIT video head impulse test References 1 Al-AniR

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