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Of the glutathionylation-related enzymes, the glutathione S-transferases (GSTs) superfamily was classically identified as phase II detoxifying enzymes that contribute to neutralizing exogenous as well as endogenous electrophiles, including ROS, through the conjugation of glutathione (GSH) 9,10,11

Patients received either pemetrexed 500 mg/m2 intravenously and cisplatin 75 mg/m2 intravenously on Day 1 of each 21-day cycle (n=839) or gemcitabine 1,250 mg/m2 intravenously on Days 1 and 8 and cisplatin 75 mg/m2 intravenously on Day 1 of each 21-day cycle (n=830)

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