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Description

Preservation of these spaces may facilitate regenerative cells and growth factors infiltration and more sustained exposure of biologic agents and their signaling mediators, thereby supporting tissue remodeling

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Additionally, GPxs due to their subcellular compartmentalization (cytoplasmic, membrane, ER, and mitochondrial localizations) control the local concentration gradient of peroxides and thereby regulate the activation/deactivation of redox-responsive signaling pathways [1, 8,9,10]