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FUNDING This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) RS-2023-00208709 (to Kyu Chang Won) and a grant from the Korea governments Institute of Information and Communications Technology Planning & Evaluation (IITP) (RS-2022-II220965), Development of diabetes patients healthcare digital twin technology based on continuous lifelog variables

For instance, experiments involving high-iron diets or the depletion of Gpx4 , which induces ferroptosis, promote pancreatitis and pancreatic tumorigenesis in mice [209, 210]

Finally, the tumor selectivity of ferroptosis inducerswhy they spare normal kidney tissue (234, 245)lacks a molecular explanation

whether these cell death modalities crosstalk to amplify injury or compensate for each other in the transition phase lacks systematic investigation