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Interestingly, they do not contain any sequence homology to other known mitochondrial carrier proteins, such as the phosphate carrier PiC or the adenosine nucleotide transporter ANT, as was previously proposed [58]

Erastin inhibits system Xc to lower GSH, reverses the Warburg effect, and thus primes mitochondria to amplify copper-mediated cuproptosis, culminating in irreversible mitochondrial damage

Sci Transl Med 7(274):274ra17 Wang JB, Erickson JW, Fuji R et al (2010) Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

This process supports cellular regeneration, reduces inflammation, and enhances the bodys ability to recover from oxidative stress