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Berman E, Arlin Z, Daghestani A, Gee T, Kempin S, Mertelsmann R, Andreeff M , Hancock R, Baratz R, Williams L, Clarkson B, Young C

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Metabolic disturbances also play a key role, including SIRT1/NAD + pathway dysfunction causing mitochondrial impairment, ceramide accumulation leading to lipotoxic injury, and ferroptosis exacerbating cellular damage