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Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma

For example, Pt drugs prolong Nav1.6 open times and increase persistent current in DRG neurons, which aggravate cold abnormal pain (Sittl et al., 2012)