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Description

Int Ophthalmol Clin

In this case, the mechanism of down-regulation is linked to promoter methylation (Scalise et al., 2012

However, methylation and glutathione production are connected through homocysteine and the transsulfuration pathway

The prolonged opening of this pore affects the redox state of the mitochondria, impairs oxidative phosphorylation, and activates apoptosis, ultimately leading to cell death