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J Nutr 2008, 138 (6), 10391046

In MDD, a decrease in the number of astrocytes may lead to an imbalance in neurotransmission, synaptic connectivity, and metabolism (O'Leary and Mechawar, 2021)

These structural rearrangements reduce the distance between the two intracellular kinase domains, and thus promote trans-autophosphorylation and activation