Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: relevance in age-associated vascular dysfunction
Protein extraction was performed as previously described 95,96 with modifications
Moreover, under the catalysis of HO-1, heme could eventually be catabolized to bilirubin, which was confirmed to be an endogenous cytoprotective molecule because of its ability to scavenge peroxyl radicals (Calabrese et al
Disclosures: Shunsuke Ikejima: Nothing to Disclose, Kazuyoshi Kon: Nothing to Disclose, Kumiko Arai: Nothing to Disclose, Akira Uchiyama: Nothing to Disclose, Hiroo Fukada: Nothing to Disclose, Kyoko Fukuhara: Nothing to Disclose, Reiko Yaginuma: Nothing to Disclose, Maki Morinaga: Nothing to Disclose, Masahiro Tada: Nothing to Disclose, SHUNHEI YAMASHINA: Nothing to Disclose, Kenichi Ikejima: Nothing to Disclose 627 FIBROBLAST GROWTH FACTOR 15/19 (FGF15/19) REGULATES CIRCADIAN ENERGY METABOLISM IN SHIFT WORKERS Zhenning Yang 1 Bo Kong 1 Mingzhu Fang 2 Rulaiha Taylor 1 Helmut Zarbl 1 Grace Guo 1 , 1 Rutgers University, 2 Bristol Myers Squibb Background: Chronic disruption of circadian rhythm by shift work is an important risk factor for metabolic diseases
