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1 Introduction Cardiovascular diseases are currently the leading cause of premature death and disability worldwide, with ischemic heart disease and stroke being the main culprits ( Luteolin is the most common flavonoid in many vegetables, fruits, and herbs

Long-term HFD consumption increased hepatic IKK- glutathionylation and NF-B suppression The mechanistic investigations in our cell culture studies provided evidence suggesting that intracellular GSSG accumulation sensitizes hepatocytes to TNF cytotoxicity via the induction of IKK- glutathionylation, leading to reduced IKK- phosphorylation and subsequent NF-B suppression

doi: 10.1039/D3FO00122A 147

While both folic acid and vitamin B 12 are required for normal Met synthase activity, vitamin B 6 serves as a key cofactor necessary for the activity of CS