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In whole, the data of different studies show that the concentration of 4-HNEs in the cell is important for the activation of the cell cycle and signal cascades regulating cell differentiation, proliferation, and apoptosis, the level of 4-HNEs being strongly dependent on the activity of GSTA4-4 both in the cytoplasm and in the mitochondria

Despite their historic popularity and effectiveness with nearly every disease, they have not been studied nearly as much as you would expect