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This reduction in NAD + was accompanied by decreased SIRT1 mRNA levels, suggesting that SYNCRIP may regulate both the abundance and functional capacity of SIRT1 (Figure S4I)

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[2] The Phase 3a REDEFINE 2 trial then tested once-weekly CagriSema (cagrilintide 2.4 mg plus semaglutide 2.4 mg) against placebo in 1,206 adults with obesity and type 2 diabetes over 68 weeks, reporting a mean bodyweight change of 13.7% versus 3.4% for placebo