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For the safest oral options, use liposomal and acetylated forms, which absorb better without any digestive issues

doi: 10.1016/j.physbeh.2018.02.006

doi: 10.1016/S1473-3099(25)00118-5 [DOI] [PMC free article] [PubMed] [Google Scholar] 9.Vakov J, Koan L, Vako L, Perjsi P

Furthermore, methadone is also an N -methyl-d-aspartate (NMDA) receptor antagonist, and this property has been implicated in a role of preventing tolerance to methadone