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Severe Respiratory or Critical Illness : Those with significant respiratory impairment or who are recovering from major surgeries or trauma (such as open-heart surgery, abdominal surgery, or multiple injuries) are at increased risk of complications with Sermorelin

Borgia P, Baldassari S, Pedemonte N, Alkhunaizi E, DOnofrio G, Tortora D, Cali E, Scudieri P, Balagura G, Musante I, Diana MC, Pedemonte M, Vari MS, Iacomino M, Riva A, Chimenz R, Mangano GD, Mohammadi MH, Toosi MB, Ashrafzadeh F, Imannezhad S, Karimiani EG, Accogli A, Schiaffino MC, Maghnie M, Soler MA, Echiverri K, Abrams CK, Striano P, Fortuna S, Maroofian R, Houlden H, Zara F, Fiorillo C, Salpietro V (2022) Genotype-phenotype correlations and disease mechanisms in PEX13-related Zellweger spectrum disorders

This non-covalently bound component was identified as protoheme (also called hematin), consisting of an iron atom and a porphyrin ring