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Mechanism of action : Perampanel is a selective, non-competitive AMPA-type glutamate receptor antagonist

M., Macgibbon, K

Immunohistochemistry and hematoxylin and eosin (H&E) staining Mice were anesthetized and transcardially perfused with cold PBS followed by 4% paraformaldehyde (PFA, Beyotime, Cat

These results identify ABCC1 and glutathione metabolism as mechanisms limiting efficacy of BCL-2 inhibitors, which may pave the way to development of more effective therapies