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doi: 10.1681/ASN.2016040385

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Renal dosing adjustments for adult patients with HABP/VABP per estimated CrCl (mL/min) a,b a,b 30 to 50 CrCl (mL/min) 1.5 g (1 g and 0.5 g) intravenously every 8 hours 15 to 29 CrCl (mL/min) 750 mg (500 mg and 250 mg) intravenously every 8 hours For patients with end-stage renal disease on hemodialysis: a single loading dose of 2.25 g (1.5 g and 0.75 g) followed by a 450-mg (300 mg and 150 mg) maintenance dose administered intravenously every 8 hours for the remainder of the treatment period (on hemodialysis days, administer the dose at the earliest possible time following completion of dialysis)