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When tumors reached approximately 100 mm 3 , mice were randomized into four groups (sh-NC + vehicle, sh-GPX3 + vehicle, sh-NC + PX-478, sh-GPX3 + PX-478) and treated orally with the HIF-1 inhibitor PX-478 (20 mg/kg) or vehicle for five consecutive days (Fig

Transmission electron micrographs revealed that combination induces significative internal damage TEM analysis was employed to investigate and compare ultrastructural damages induced by AS, RESV alone or in combination (AS + RESV) (Fig

Iron is essential for the production of hemoglobin, which carries oxygen in the blood