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Consistent supplementation, periodic blood testing, and dose adjustment when needed are the tools that do that job

Riboflavin, specifically, is often an overlooked component of a healthy methylation pathway and may help with migraines, fatigue, and lowering homocysteine levels in my experience

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Diagnosis typically involves a combination of lab testing (e.g., tryptase, histamine, prostaglandins, chromogranin A), symptom correlation, and clinical evaluation