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320 Similar protective roles are observed in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), where HSP70 and HSP90 suppress the aggregation of TDP-43, a protein that forms pathological cytoplasmic inclusions in affected neurons

266,267,268 Recently, C5aR expression has also been identified in a range of non-myeloid cells across multiple organs, with notable abundance in the lungs and liver