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Consistent with other APCM service elements, we will require that the efforts to reach the patient/caregiver and any interaction must be documented in the patient's medical record

This would need to be followed by 100 to 1,000 mcg administered by injection every one to three months

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Preclinical Studies Cerebral Ischemia: PMID: 34201112 Brain Protein Expression Profile Confirms the Protective Effect of Semax in Cerebral Ischemia-Reperfusion (2021) PMID: 32580520 Novel Insights Into the Protective Properties of Semax at the Transcriptome Level (2020) PMID: 28255762 Semax Regulates Expression of Immune Response Genes During Ischemic Brain Injury (2017) PMID: 24661604 Semax Affects Expression of Genes Related to Immune and Vascular Systems in Focal Ischemia (2014) BDNF and Neurotrophin Studies: PMID: 16635254 Semax Binds Specifically and Increases BDNF Protein in Rat Basal Forebrain (2006) PMID: 19662538 Comparison of NGF and BDNF Gene Expression Under Semax Action (2010) PMID: 17353092 Neurotrophin Gene Expression in Rat Brain Under Semax Action (2007) Other Mechanisms: PMID: 40692165 Semax Targets Opioid Receptor for Functional Recovery After Spinal Cord Injury (2025) PMID: 25310602 Semax Has High Affinity for Copper(II) and Protective Ability Against Metal Toxicity (2015) PMID: 35080861 Semax Affects Copper-Induced A Aggregation in Alzheimers Models (2022)The Peptide Semax Affects the Expression of Genes Related to the Immune and Vascular Systems in Rat Brain Focal Ischemia: Genome-Wide Transcriptional Analysis