Dual inhibition of GLUT1 and the ATR/CHK1 kinase axis displays synergistic cytotoxicity in KRAS -mutant cancer cells
Aquaporins in the human testis and spermatozoa identification, involvement in sperm volume regulation and clinical relevance
While these mechanisms differ from neuronal signalling in structure and complexity, their shared dependence on Ca 2+ , NO, and redox regulation reflects conserved cellular logic underlying stress adaptation
Various cellular activities such as growth, proliferation, apoptosis, and metastasis of tumor cells are regulated by multiple important signal cascades such as Nuclear factor erythroid 2-related factor 2 (Nrf2), Cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING), WNT/-catenin, Rat Sarcoma/Rapidly Accelerated Fibrosarcoma/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase (Ras/Raf/MEK/ERK), Epidermal growth factor receptor (EGFR), Phosphoinositide-specific Phospholipase C/Protein kinase C (PLC/PKC), Phosphoinositide 3-Kinase/Protein kinase B (PI3K/AKT), Notch Receptor (NOTCH), Platelet-derived growth factor (PDGF), Vascular Endothelial Growth Factors (VEGF), Cellular-mesenchymal epithelial transition factor (c-MET), Yes-associated protein/Transcriptional Enhanced Associate Domains (YAP/TEAD), Phospho P38 mitogen-activated protein kinase/Mitogen-activated protein kinase/Extracellular regulated protein kinases (P38/MAPK/Erk), Toll-like receptors (TLR) etc.) [66,67,68,69,70,71,72,73,74,75]
