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When proliferating chondrocytes mature, they increase the production of Ihh, which acts on its receptor Patched in the neighboring cells via unknown mechanisms to increase the production of PTHrP (39), thus slowing down cell differentiation to prevent early closure of the growth plate (Figure 1)

Tanaka T, Lavery R, Varma V, Fantoni G, Colpo M, Thambisetty M, Candia J, Resnick SM, Bennett DA, Biancotto A, Bandinelli S, Ferrucci L (2020) Plasma proteomic signatures predict dementia and cognitive impairment

Women with hypoactive sexual desire disorder and men experiencing sexual dysfunction not addressed by other approaches