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Targeting GPX4 and ferroptosis in AML The role of GPX4 in the development of the myeloid lineage and in the initiation and progression of myeloid leukemia remains poorly explored

One to three Brazil nuts daily typically provides adequate selenium for most individuals, though excessive intake should be avoided as selenium toxicity can occur with chronic overconsumption

Using a standard curve, the antioxidant capacity of the samples was recorded 58

Seahorse analysis The mitochondrial bioenergetics of HEB, U87, and T98G cells, in response to metformin and simvastatin, were assessed using a Seahorse XFe96 Analyzer (Agilent Technologies, USA)