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Metformin also downregulates TLR4-NF-B signaling in podocytes, decreasing pro-inflammatory cytokine production and MCP-1-driven macrophage infiltration (108)

Using them together means you're not relying on one pathway when you could be addressing two simultaneously

Identification and structural elucidation of the metabolites are performed by comparing their changes in molecular masses (DeltaM), retention-times and full scan MSn spectra with those of the parent drug