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[] In the latter one, insulin activates ATP-sensitive potassium (K ATP ) channels in the outer membranes of neurons in the hypothalamus, and subsequently, generates an efferent vagal impulse to the liver (the hepatic branch of vagus nerve comprising both efferent fibers and afferent fibers) required for inhibiting hepatic glucose production [] [Figure 7]

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Sotalol treatment may interfere with retrieval, expression, and/or reconsolidation processes thus disrupting traumatic memories in a post-traumatic stress disorder mice model

Despite promising preclinical findings, challenges such as specificity, safety, and clinical translation remain unresolved.6 This review aims to explore recent advancements in senolytics and senomorphics, their therapeutic potential, and the challenges in translating these strategies into clinical applications for enhancing longevity and healthspan