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Glutathione metabolism was also significantly disrupted, as reflected by elevated pyroglutamic acid and glutamyl-amino acids alongside reduced glutamine, consistent with impaired antioxidant defense and redox imbalance

Pathogens 14, 308

(2020) reported that increased levels of proinflammatory cytokines (IL-1 and IL-18) and ASC were detected in serum samples from patients with severe AP