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HO-1 is in charge of the oxidation of the heme groups free of ferrous iron (Fe2+), carbon monoxide, and biliverdin, the latter being reduced to bilirubin by biliverdin reductase, which acts as a fat-soluble antioxidant [32]

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Sato A, Itcho N, Ishiguro H, Okamoto D, Kobayashi N, Kawai K, et al