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As skill increases, the effectiveness of P.E.D.s decreases

STAT3 is a crucial factor in maintaining cell proliferation and survival, and can be activated by various cytokines to mediate immune and inflammatory responses (Figure 10)

Furthermore, the Wnt/-catenin pathway has many homologues at different levels and is involved in different signal transduction pathways, possibly leading to the redundancy and adaptation of organisms to a lack of specific genes