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The release of bacterial metabolites provides a possible link between the gut and the brain

Additionally, multiple DAMPs can regulate ferroptosis, such as: IFNs can regulate solute carrier family 7a member 11 (SLC7A11, subunit of xCT) and GPX4 expression by activating JAK-STAT1 signaling (8)

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Although it is well known that sufficient physiological levels of reactive oxygen species (ROS) are necessary for the processes of physiological adaptation to exercise training, overtraining, insufficient energy supply, or poor sleep hygiene may increase the ROS production, which in turn may have a negative impact on the time course of exercise-induced adaptations [140,141,142]