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The luminescence intensity was measured using the VERITAS microplate luminometer (Turner Biosystems)

It takes approximately 4 to 5 half-lives for plasma concentrations to reach about 97% of their final steady-state value .8 Factors Influencing the Level of C ss While the time to reach steady state is dependent only on half-life, the level or magnitude of the steady-state concentration is determined by the balance between the dosing rate and the drug's clearance

This GSH-mediated gene induction occurs via S -nitosylation of the Fe responsive basic helix loop helix (bHLH) transcription factors (TFs), bHLH29, bHLH38, and bHLH101