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It is worth noting that Fig.3 highlights four major issues affecting the effectiveness and safety of Se-based treatments: (1) a narrow therapeutic window requiring precise dosing to avoid toxicity or ineffectiveness

Rapid determination of four major amino acids in soft-shelled turtle shell gelatin by UPLC-MS/MS

Brandes, N., Reichmann, D., Tienson, H., Leichert, L.I

This might help treating physicians in making the right decisions on how to intervene and improve metabolism for the benefit of patients, and to understand why and how metabolism responds in their specific cases