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At its IC50 concentration, vincristine induced significant downregulation of Ribonucleotide Reductase M2 (RRM2), involved in DNA damage repair and cell cycle regulation ( Supplementary Table S1 )

The targeted delivery of dexamethasone to GLP1R-positive cells prevented typical dexamethasone offtarget effects on glucose metabolism, bone density, and the hypothalamus-pituitary-adrenal axis activity (164)

Furthermore, DAG generated by PNPLA2 preferentially produces 1,3- DAG which cannot activate PKC (196), suggesting that the de novo generation of DAGs leads to insulin resistance

While MS was initially suspected, given the history of optic neuritis and paresthesia, this diagnosis was ruled out on the basis of normal MRI findings and the absence of spinal cord involvement or demyelinating lesions