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The detrimental effect of oxidative stress is usually accompanied by changes in antioxidant defense mechanisms, with the alterations in antioxidant enzymes expression/activities during MASLD development and progression reported in many clinical and experimental studies

In addition, dysfunction of the Xc- system in ferroptosis leads to increased Glu concentration, causing neuroexcitotoxicity

In the future, this architecture will enable the development of predictive, quantitative computational models to identify combination therapies, clinical solutions, and strategies to minimize adverse side effects

10.1161/CIRCIMAGING.123.015490 Summary Keywords -thalassemia, iron overload, myocardial injury, treatment, early identification Citation Fu C and Yang X (2025) Cardiac injury caused by iron overload in thalassemia